The first non-U.S. chapter of Omega Psi Phi, a predominantly African-American fraternity, was established on campus in 1923. Ernest Melville DuPorte, who would later become a professor at Macdonald Campus, was one of its founding members.
The fraternity was never mentioned in the McGill Daily, nor was it included in the list of fraternities in the yearbook. In the 1930s, the chapter became inactive and left McGill.